Frans J Walther Selected Research

Right Ventricular Hypertrophy

1/2017	Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation.
8/2015	Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response.
8/2014	Angiotensin II type 2 receptor ligand PD123319 attenuates hyperoxia-induced lung and heart injury at a low dose in newborn rats.
9/2013	Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury.
2/2013	Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and vascular development in neonatal rats with hyperoxic lung injury.
1/2012	Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats.
11/2010	Apelin attenuates hyperoxic lung and heart injury in neonatal rats.
4/2009	Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury.

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Frans J Walther Research Topics

Disease

17	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022 - 12/2002
14	Hyperoxia 01/2018 - 03/2004
14	Lung Injury 01/2018 - 11/2004
10	Bronchopulmonary Dysplasia 01/2022 - 04/2006
9	Lung Diseases (Lung Disease) 01/2017 - 04/2006
8	Right Ventricular Hypertrophy 01/2017 - 04/2009
8	Pneumonia (Pneumonitis) 01/2017 - 07/2007
8	Inflammation (Inflammations) 08/2015 - 11/2004
8	Fetofetal Transfusion (Twin Transfusion Syndrome) 06/2014 - 11/2005
6	Infections 12/2017 - 05/2006
6	Anemia 03/2012 - 05/2006
5	Acute Lung Injury 01/2017 - 01/2007
4	Newborn Respiratory Distress Syndrome 01/2022 - 12/2002
3	Patent Ductus Arteriosus 01/2020 - 01/2012
3	Respiratory Insufficiency (Respiratory Failure) 01/2018 - 07/2012
3	Fibrosis (Cirrhosis) 01/2017 - 08/2014
3	Neonatal Alloimmune Thrombocytopenia 01/2015 - 01/2006
3	Hypertension (High Blood Pressure) 08/2014 - 10/2011
3	Body Weight (Weight, Body) 06/2010 - 04/2009
2	Pulmonary Arterial Hypertension 08/2015 - 02/2013
2	Heart Injuries 08/2014 - 11/2010
2	Erythema Infectiosum (Fifth Disease) 03/2012 - 01/2007
2	Pulmonary Hypertension 01/2012 - 04/2009
2	Birth Weight (Birth Weights) 10/2010 - 02/2009
2	Hyperglycemia 07/2010 - 10/2003
2	Edema (Dropsy) 01/2007 - 11/2004
1	Sepsis (Septicemia) 12/2017
1	Type 2 Diabetes Mellitus (MODY) 08/2015
1	Thrombocytopenia (Thrombopenia) 01/2015
1	Surfactant Dysfunction 01/2014
1	Apnea 08/2013
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 08/2012
1	Bipolar Disorder (Manic Depressive Psychosis) 06/2012
1	Necrotizing Enterocolitis 01/2012

Drug/Important Bio-Agent (IBA)

18	Surface-Active Agents (Surfactants)IBA 01/2022 - 01/2002
8	Proteins (Proteins, Gene)FDA Link 01/2018 - 11/2004
8	Messenger RNA (mRNA)IBA 01/2017 - 04/2006
7	Peptides (Polypeptides)IBA 10/2021 - 12/2002
6	FibrinIBA 08/2015 - 11/2004
5	LipidsIBA 10/2021 - 01/2007
4	Intravenous Immunoglobulins (IVIG)FDA Link 01/2015 - 01/2006
4	Oxygen (Dioxygen)IBA 08/2013 - 11/2010
4	Phospholipases (Phospholipase)IBA 12/2011 - 10/2007
4	Immunoglobulin M (IgM)IBA 01/2007 - 05/2006
3	IgA receptor (protein B)IBA 10/2021 - 12/2002
3	Ibuprofen (Motrin)FDA LinkGeneric 01/2020 - 01/2012
3	CytokinesIBA 01/2017 - 07/2007
3	DNA (Deoxyribonucleic Acid)IBA 01/2007 - 03/2004
2	AerosolsIBA 01/2022 - 12/2021
2	Blood Glucose (Blood Sugar)IBA 08/2015 - 07/2010
2	AngiotensinsIBA 08/2014 - 09/2013
2	Vasoconstrictor AgentsIBA 09/2013 - 02/2013
2	Endothelin-1 (Endothelin 1)IBA 02/2013 - 01/2007
2	SteroidsIBA 08/2012 - 10/2010
2	Secretory Phospholipases A2IBA 01/2010 - 11/2008
2	EnzymesIBA 01/2010 - 11/2008
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2007 - 01/2007
1	PowdersIBA 12/2021
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2018
1	Leucine (L-Leucine)FDA Link 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	Pioglitazone (Actos)FDA Link 01/2018
1	Blood Coagulation Factors (Coagulation Factor)IBA 01/2017
1	Growth Differentiation Factor 2IBA 01/2017
1	lysophosphatidic acidIBA 01/2017
1	Indicators and Reagents (Reagents)IBA 01/2017
1	LipopolysaccharidesIBA 01/2017
1	Lysophosphatidic Acid ReceptorsIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	ChemokinesIBA 01/2017
1	Therapeutic UsesIBA 01/2016
1	Metformin (Glucophage)FDA LinkGeneric 08/2015
1	Pharmaceutical PreparationsIBA 08/2015
1	CollagenIBA 08/2015
1	Type 2 Angiotensin ReceptorIBA 08/2014
1	LigandsIBA 08/2014
1	PD 123319IBA 08/2014
1	calfactant (Infasurf)FDA Link 01/2014
1	Angiotensin IIIBA 09/2013
1	ambrisentan FDA Link 02/2013
1	Endothelin Receptors (Endothelin Receptor)IBA 02/2013
1	Naloxone (Narcan)FDA LinkGeneric 07/2012
1	LithiumIBA 06/2012
1	Antihypertensive Agents (Antihypertensives)IBA 01/2012
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2012
1	piclamilastIBA 01/2012
1	Phosphodiesterase 4 InhibitorsIBA 01/2012
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2012
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 01/2012

Therapy/Procedure

7	Laser Therapy (Surgery, Laser) 06/2014 - 05/2006
5	Therapeutics 01/2018 - 10/2003
5	Intrauterine Blood Transfusion 03/2012 - 05/2006
3	Platelet Transfusion (Blood Platelet Transfusions) 01/2015 - 01/2007
3	Continuous Positive Airway Pressure 01/2014 - 02/2007
2	Critical Care (Surgical Intensive Care) 12/2017 - 02/2008
2	Lasers (Laser) 03/2007 - 11/2005
1	Artificial Respiration (Mechanical Ventilation) 01/2022
1	Noninvasive Ventilation 01/2022
1	Perinatal Care 01/2018
1	Resuscitation 07/2012